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© 1984 Oxford University Press

research-article

Assessment of the Cataractogenic Potential of Cyclohexanone in Guinea Pigs and Rabbits1

YIGAL GREENER and EUGENE YOUKILIS

Department of Safety Assessment, Travenol Laboratories, Inc. 6301 Lincoln Avenue, Morton Grove, Illinois 60053

Assessment of the Cataractogenic Potential of Cyclohexanone in Guinea Pigs and Rabbits. GREENER, Y., AND YOUKIUS, E. (1984). Fundam. Appl. Toxicol. 4, 1055–1066. The cataractogenic potential of cyclohexanone administered intravenously (0.5 and 5.0 mg/kg) and percutaneously (0.5 ml) was assessed in guinea pigs and rabbits. The negative control article was 0.9% sodium chloride. Positive control articles for guinea pigs were iv galactose and percutaneous dimethyl sulfoxide (DMSO), and for rabbits, iv poly(l). poly(C) and percutaneous DMS0. An untreated group of guinea pigs was used as a sham control. Animals were treated three times a week for 3 consecutive weeks. Ophthalmic examinations performed monthly for 6 months for treated animals and 7 months for untreated animals revealed the presence of anterior subcapsular vacuoles in guinea pigs in all groups. These lesions consisted of swollen lens fibers that progressed to fiber disruption and protein liquefaction. There was no statistical difference in the incidence and severity of the lesions among treatment groups. No lenticular alterations were noted in any of the rabbits treated with cyclohexanone or any other chemical. It was concluded that these alterations are, apparently, an inherent characteristic of the guinea pig, making that animal an unsuitable model for the assessment of cataractogenic potential of xenobiotics.


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