© 1998 Oxford University Press
other |
Comparative Carcinogenicity in Sprague-Dawley Rats of the Polychlorinated Biphenyl Mixtures Aroclors 1016, 1242, 1254, and 1260
*General Electric Corporate Research & Development Scheneclady, New York
ToxPath, Inc. Raleigh, North Carolina
Jellinek, Schwartz & Connolly, Inc. Arlington, Virginia
Battelle Laboratories Columbus, Ohio
¶General Electric Co. Fairfield, Connecticut
|Institute for Evaluating Health Risks Washington, DC
Received August 28, 1997; accepted October 22, 1997
A comprehensive chronic toxicity and carcinogenicity study was conducted on a series of Aroclors (1016, 1242, 1254, and 1260). Each Aroclor was assessed at multiple dietary concentrations, ranging from 25 to 200 ppm, for 24 months in male and female Sprague-Dawley rats. Liver toxicity was indicated by elevated serum enzyme activity (AST, ALT, and GGT), elevated serum cholesterol concentration, decreases in hematologic parameters (RBC, Hb, and Hct), hepatocellular hypertrophy, an increased incidence of altered hepatocellular foci, and an increased incidence of hepatocellular neoplasms (primarily adenomas). Liver toxicity was distinctly more severe in females than in males. The incidence of hepatocellular neoplasms was highly sex-dependent (females > males), differed between Aroclor mixtures and, for females, increased with dose and followed the general incidence pattern of Aroclor 1254 > Aroclor 1260 
Aroclor 1242 > Aroclor 1016. A significant response (p < 0.05) in males was seen only for the high dose of Aroclor 1260. A small increase in the incidence of thyroid gland follicular cell adenomas was noted in males for Aroclors 1242, 1254, and 1260, with the incidence being uniform across dose groups and Aroclor mixtures. For females, increased survival relative to controls was observed for all Aroclor treatment groups. A significantly decreased trend in the incidence of mammary gland neoplasms compared to control was also noted for females receiving Aroclors 1242, 1254, and 1260.
Key Words: PCB; polychlorinated biphenyls; Aroclor; Aroclor 1016; Aroclor 1242; Aroclor 1254; Aroclor 1260; cancer; carcino-genicity; rat; Sprague-Dawley; mammary tumors; liver tumors; thyroid tumors; sex difference; risk assessment.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. B. Silkworth, E. A. Carlson, C. McCulloch, K. Illouz, S. Goodwin, and T. R. Sutter Toxicogenomic Analysis of Gender, Chemical, and Dose Effects in Livers of TCDD- or Aroclor 1254-Exposed Rats Using a Multifactor Linear Model Toxicol. Sci., April 1, 2008; 102(2): 291 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Walker, K. Yoshizawa, R. A. Miller, A. E. Brix, D. M. Sells, M. P. Jokinen, M. E. Wyde, M. Easterling, and A. Nyska Pulmonary Lesions in Female Harlan Sprague-Dawley Rats Following Two-Year Oral Treatment with Dioxin-Like Compounds Toxicol Pathol, December 1, 2007; 35(7): 880 - 889. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Zettner, S. Flor, G. Ludewig, J. Wagner, L. W. Robertson, and L. Lehmann Quinoid Metabolites of 4-Monochlorobiphenyl Induce Gene Mutations in Cultured Chinese Hamster V79 Cells Toxicol. Sci., November 1, 2007; 100(1): 88 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Brown Jr, B. A. Mayes, J. B. Silkworth, and S. B. Hamilton Polychlorinated Biphenyls Modulated Tumorigenesis in Sprague Dawley Rats: Correlation with Mixed Function Oxidase Activities and Superoxide (O2* ) Formation Potentials and Implied Mode of Action Toxicol. Sci., August 1, 2007; 98(2): 375 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lehmann, H. L.Esch, P. A.Kirby, L. W.Robertson, and G. Ludewig 4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats Carcinogenesis, February 1, 2007; 28(2): 471 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Shields Understanding population and individual risk assessment: the case of polychlorinated biphenyls. Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 830 - 839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Silkworth, A. Koganti, K. Illouz, A. Possolo, M. Zhao, and S. B. Hamilton Comparison of TCDD and PCB CYP1A Induction Sensitivities in Fresh Hepatocytes from Human Donors, Sprague-Dawley Rats, and Rhesus Monkeys and HepG2 Cells Toxicol. Sci., October 1, 2005; 87(2): 508 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Desaulniers, G.-H. Xiao, K. Leingartner, I. Chu, B. Musicki, and B. K. Tsang Comparisons of Brain, Uterus, and Liver mRNA Expression for Cytochrome P450s, DNA Methyltransferase-1, and Catechol-O-Methyltransferase in Prepubertal Female Sprague-Dawley Rats Exposed to a Mixture of Aryl Hydrocarbon Receptor Agonists Toxicol. Sci., July 1, 2005; 86(1): 175 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Lu, E. Y. Lee, L. W. Robertson, H. P. Glauert, and B. T. Spear Effect of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB-153) on Hepatocyte Proliferation and Apoptosis in Mice Deficient in the p50 Subunit of the Transcription Factor NF-{kappa}B Toxicol. Sci., September 1, 2004; 81(1): 35 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Espandiari, H. P. Glauert, H.-J. Lehmler, E. Y. Lee, C. Srinivasan, and L. W. Robertson Initiating Activity of 4-Chlorobiphenyl Metabolites in the Resistant Hepatocyte Model Toxicol. Sci., May 1, 2004; 79(1): 41 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Dean Jr., S. A. Benjamin, L. S. Chubb, J. D. Tessari, and T. J. Keefe Nonadditive Hepatic Tumor Promoting Effects by a Mixture of Two Structurally Different Polychlorinated Biphenyls in Female Rat Livers Toxicol. Sci., March 1, 2002; 66(1): 54 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Whysner and C.-X. Wang Hepatocellular Iron Accumulation and Increased Cell Proliferation in Polychlorinated Biphenyl-Exposed Sprague-Dawley Rats and the Development of Hepatocarcinogenesis Toxicol. Sci., July 1, 2001; 62(1): 36 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. M Faroon, S. Keith, D. Jones, and C. De Rosa Carcinogenic effects of polychlorinated biphenyls Toxicology and Industrial Health, March 1, 2001; 17(2): 41 - 62. [Abstract] [PDF]
|
|
|
|
|
|
A. Srinivasan, H.-J. Lehmler, L. W. Robertson, and G. Ludewig Production of DNA Strand Breaks in Vitro and Reactive Oxygen Species in Vitro and in HL-60 Cells by PCB Metabolites Toxicol. Sci., March 1, 2001; 60(1): 92 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Bagga, K. H. Anders, H.-J. Wang, E. Roberts, and J. A. Glaspy Organochlorine Pesticide Content of Breast Adipose Tissue From Women With Breast Cancer and Control Subjects J Natl Cancer Inst, May 3, 2000; 92(9): 750 - 753. [Full Text] [PDF]
|
|
|
|
|
|
G. B. Freeman, R. A. Lordo, A. W. Singer, A. C. Peters, B. H. Neal, E. E. McConnell, and B. A. Mayes An Assessment of Neurotoxicity of Aroclors 1016, 1242, 1254, and 1260 Administered in Diet to Sprague-Dawley Rats for One Year Toxicol. Sci., February 1, 2000; 53(2): 377 - 391. [Abstract] [Full Text] [PDF]
|
|