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© 1998 Oxford University Press

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Acute Respiratory Exposure of Human Volunteers to Octamethylcyclotetrasiloxane (D4): Absence of Immunological Effects

R. J. Looney*, M. W. Frampton*, J. Byam*, C. Kenaga*, D. M. Speers*, C. Cox*, R. Mast{dagger}, P. C. Klykken{ddagger}, P. E. Morrow* and M. J. Utell*

*University of Rochester School of Medicine Rochester, New York 14642 {dagger}Everest Consulting Associates Midland, Michigan 48686 {ddagger}Dow Corning Corporation Midland, Michigan 48686

Received September 22, 1997; accepted May 1, 1998

Humans are exposed to silicones in a number of commercial and consumer products. Some of these silicones, including octamethycy-clotetrasiloxane (D4), are volatile. Therefore, there is a potential for respiratory exposure. A pharmacokinetic analysis of respiratory exposure to D4 is presented in the accompanying paper (M. J. Utell et al., 1998, Toxicol. Sci. 44, 206–213). Possible immune effects of respiratory exposure to D4 are investigated in this paper. Normal volunteers were exposed to 10 ppm D4 or air for 1 h via a mouthpiece using a double-blind, crossover study design. Assays were chosen to screen for immunotoxicity or a systemic inflammatory response. Assessment of immunotoxicity included enumeration of peripheral lymphocyte subsets and functional assays using peripheral blood mono-nuclear cells. Because in humans there is no direct test for adjuvant effect of respiratory exposure, we analyzed proinflammatory cyto-kines and acute-phase reactants in peripheral blood, markers for a systemic inflammatory response, as surrogate markers for adjuvancy. These tests were repeated when the volunteers were reexposed to D4 approximately 3 months after this initial exposure. Blood was obtained prior to exposure, immediately postexposure, and 6 and 24 h postexposure. In these short-term, controlled human exposures, no immunotoxic or proinflammatory effects of respiratory exposure to D4 Were found.


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 International Journal of ToxicologyHome page
L. A. Burns-Naas, R. G. Meeks, G. B. Kolesar, R. W. Mast, M. R. Elwell, J. F. Hardisty, and P. Thevenaz
Inhalation Toxicology of Octamethylcyclotetrasiloxane (D4) Following a 3-Month Nose-Only Exposure in Fischer 344 Rats
International Journal of Toxicology, January 1, 2002; 21(1): 39 - 53.
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