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© 1998 Oxford University Press
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Symposium Overview: Chemical Modulation of Neuroreceptors and Channels via Intracellular Components1
*Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School Chicago, Illinois 60611
Department of Pharmacology and Molecular Toxicology, University of Massachusetts Medical Center Worcester, Massachusetts 01655-0126
Department of Molecular and Cellular Physiology, University of Cincinnati Medical Center Cincinnati, Ohio 45267
Department of Comparative Biosciences, University of Wisconsin Madison, Wisconsin
¶Department of Pharmacology and Toxicology, Michigan State University East Lansing, Michigan 48824-1317
Received January 13, 1998; accepted January 23, 1998
Whereas the roles of G option and protein kinases in various neuroreceptors and ion channels have been studied extensively, their roles in the actions of drugs and toxicants on these receptors and channels remain to be elucidated. Almost all drugs and toxicants exert multiple actions on multiple target sites, and there is no reason to assume that a chemical modulates a receptor/channel via a single mechanism. In fact, experimental evidence is slowly but steadily being accumulated to indicate that certain drug and toxicants modulate neuroreceptor/channel functions through interactions with intracellular components such as G proteins and protein kinases Multiple actions of a toxicant on various receptors/channels may be explained on the basis of its interaction with the G protein/kinase system that is a common denominator of the target sites This is a virgin field that promises a quantum leap in the coming years. Each presention and discussion will focus on expected future developments and potential significance in the field of neurotoxicology.