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© 1998 Oxford University Press

other

Oncogenic Studies with Felbamate (2-Phenyl-1,3-propanediol Dicarbamate)

J. H. McGee*, W. H. Butler{dagger}, D. J. Erikson* and R. D. Sofia*

*Wallace Laboratories P.O. Box 1001, Cranbury, New Jersey 08512 {dagger}Toxicology Consultant Bletchingley, Surrey, Great Britain

Received January 16, 1998; accepted May 19, 1998

Felbamate, 2-phenyl-1,3-propanediol dicarbamate, is a novel anticonvulsant that is effective against both chemically and electrically induced seizures in laboratory animals. Oncogenic studies were conducted in mice and rats to establish a preclinical safety profile for this drug. There was an increased incidence of hepatic cell adenoma in male and female mice and in female rats. There was an increased incidence of interstitial cell tumors of the testes in the male rat.


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