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© 1998 Oxford University Press

research-article

Chronic Dietary Toxicity/Oncogenicity Studies on 2,4-Dichlorophenoxybutyric Acid in Rodents1

Jeffrey M. Charles*,2 and Nicholas M. Leeming{dagger}

*Charles & Conn, LLC Durham, North Carolina 27705 {dagger}A. H. Marks and Company Ltd. Wyke Bradford, West Yorkshire, England

Received March 11, 1998; accepted May 19, 1998

2,4-Dichlorophenoxybutyric acid (2,4-DB) is principally used in the United States on peanuts, soybeans, and alfalfa. In Europe, it is used on cereals, undersown cereals, lucerne (alfalfa), clover, and clover mixtures. Doses in the 2-year chronic/oncogenicity rat study were 0, 60, 600, and 1800 ppm. No evidence of an oncogenic potential for 2,4-DB was evident and the study clearly established a NOEL of 2.48 mg/kg/day (60 ppm, males) and 3.23 mg/kg/day (60 ppm, females), as well as an MTD of 78.0 (1800 ppm, males) and 110.6 mg/kg/day (1800 ppm, females), for chronic effects of 2,4-DB in the rat Doses in the 18-month mouse oncogenicity study were 0, 25, 250, and 750 ppm. No oncogenic effect was noted in the study. In summary, the findings of these studies indicate low chronic toxicity of 2,4-DB and the lack of oncogenic response to 2,4-DB following chronic dietary exposure of 2,4-DB in the rat and mouse.

Key Words: 2,4-dichlorophenoxybutyric acid; 2,4-DB; chronic toxicity; oncogenicity; herbicide; dietary; thyroid; kidney.


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