Toxicological Sciences, Vol 47, 99-109, Copyright © 1999 by Society of Toxicology
GP Schoenig, TG Osimitz, KL Gabriel, R Hartnagel, MW Gill and EI Goldenthal
Chronic toxicity and/or oncogenicity studies were conducted in rats, mice,
and dogs with the insect repellent DEET. DEET was mixed in the diet and
administered to CD rats for two years at concentrations that corresponded
to dosage levels of 10, 30 or 100 mg/kg/day for males and 30, 100, or 400
mg/kg/day for females; to CD-1 mice for 18 months at dosage levels of 250,
500, or 1000 mg/kg/day; and to dogs for one year, via gelatin capsules, at
dosage levels of 30, 100, or 400 mg/kg/day. In the rodent studies, each
group consisted of 60 animals of each sex, and two concurrent independent
control groups, each containing 60 animals/sex were included in each study.
Each group in the dog study consisted of four male and four female dogs and
one control group was included in the study. Treatment-related effects were
observed at the highest dose level in all three studies. For rats, the
effects included decreases in body weight and food consumption and an
increase in serum cholesterol in females only. In mice, the effects
observed were decreases in body weight and food consumption in both sexes.
The effects observed in dogs included increased incidences of emesis and
ptyalism, and levels of transient reduction in hemoglobin and hematocrit,
increased alkaline phosphatase (males only), decreased cholesterol, and
increased potassium. One male dog in the high-dose group also exhibited
ataxia, tremors, abnormal head movements, and/or convulsions on several
occasions during the study. The highest no- observed-effect levels (NO-ELs)
for rats, mice and dogs were determined to be 100, 500, and 100 mg/kg/day,
respectively. No specific target organ toxicity or oncogenicity was
observed in any of the studies.
ARTICLES
Evaluation of the chronic toxicity and oncogenicity of N,N-diethyl-m- toluamide (DEET)
Toxicology/Regulatory Services, Inc., Charlottesville, Virginia 22911, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. A. Ross, K. A. Savage, L. J. Utley, and I. R. Tebbett INSECT REPELLANT INTERACTIONS: SUNSCREENS ENHANCE DEET (N,N-DIETHYL-M-TOLUAMIDE) ABSORPTION Drug Metab. Dispos., August 1, 2004; 32(8): 783 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Koren Missing information on DEET Can. Med. Assoc. J., January 6, 2004; 170(1): 14 - 14. [Full Text] [PDF]
|
|
|
|
|
|
K. A. Usmani, R. L. Rose, J. A. Goldstein, W. G. Taylor, A. A. Brimfield, and E. Hodgson In Vitro Human Metabolism and Interactions of Repellent N,N-Diethyl-m-Toluamide Drug Metab. Dispos., March 1, 2002; 30(3): 289 - 294. [Abstract] [Full Text] [PDF]
|
|