Toxicological Sciences, Vol 47, 151-157, Copyright © 1999 by Society of Toxicology
MA Khan, CA Davis, GL Foley, MA Friedman and LG Hansen
High exposure to the acrylamide monomer has been associated with neuropathy
and neurotoxic effects. Chronic lower exposure causes endocrine disruption
associated with thyroid, testicular, and mammary tumors. To investigate
mechanisms of endocrine disruption, short-term, low-level oral dosing
studies were conducted. Weanling female Fischer 344 rats were acclimatized
for two weeks before dosing. Controls were given distilled water by gavage
and rats in other groups were given acrylamide at doses of 2 mg/kg/day and
15 mg/kg/day for 2 or 7 days by gavage. Twenty-four h after the last dose,
the rats were killed by decapitation. Trunk blood was collected for hormone
analyses and tissues for histopathological examination. There were no
toxicity- related deaths, no clinical signs of toxicity, and no significant
difference in the mean body weight of animal groups. Histopathological
examination of select tissues showed no lesions of pathologic significance.
Plasma thyroxine (T4), thyroid stimulating hormone (TSH), prolactin (PRL),
and pituitary TSH and PRL analyses did not reveal significant changes
between control vs. treated rats. In the 7-day study, however, there was a
slight dose-dependent increase in plasma T4 and a slight dose-dependent
decrease in plasma TSH. Thyroid gland morphometry showed a significant (p
< 0.05) decrease in the colloid area and a significant increase (p <
0.05) in the follicular cell height of treated rats as compared to
controls. The follicular area shrinkage was similar in both studies. These
results show a very early endocrine response to very low levels of toxic
insult and opens other venues to further investigate the mechanisms of
endocrine disruption by acrylamide.
ARTICLES
Changes in thyroid gland morphology after acute acrylamide exposure
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign 61802, USA.
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