Toxicological Sciences, Vol 48, 51-54, Copyright © 1999 by Society of Toxicology
Y Kato, K Haraguchi, T Shibahara, S Yumoto, Y Masuda and R Kimura
Male Sprague-Dawley rats received four consecutive intraperitoneal (i.p.)
doses of five kinds of methylsulfonyl (MeSO2) metabolites of tetra- and
pentachlorinated biphenyls (tetra- and pentaCBs) to determine their effects
on thyroid hormone levels. The five MeSO2 metabolites, which were the major
MeSO2-PCBs detected in human milk, liver and adipose tissue were
3-MeSO2-2,2',4',5-tetraCB (3-MeSO2- CB49),3-MeSO2-2,3',4',5-tetraCB
(3-MeSO2-CB70), 3-MeSO2-2,2',3',4',5- pentaCB (3-MeSO2-CB87),
3-MeSO2-2,2',4',5,5'-pentaCB (3-MeSO2-CB101), and
4-MeSO2-2,2',4',5,5'-pentaCB (4-MeSO2-CB101). All five tested MeSO2
metabolites (20 mumol/kg once daily for 4 days) reduced serum total
thyroxine levels 16-40% on days 2, 3, 4, and 7 (after the last dosage). The
total triiodothyronine level was reduced 37% by treatment with 3-
MeSO2-CB49 at day 7, but was increased 35% and 38% by 3-MeSO2-CB70 and
4-MeSO2-CB101 at days 3 and 4, respectively. The reductions in thyroid
hormone levels led to an increase in thyroid stimulating hormone (TSH)
levels by 3-MeSO2-CB49, 3-MeSO2-CB87 and 3-MeSO2-CB101. A 30% increase in
thyroid weight was produced by 3-MeSO2-CB101 treatment. Thus, it is likely
that all five tested MeSO2 metabolites could influence thyroid hormone
metabolism. The results show that the tested 3- and 4-MeSO2 metabolites of
tetra- and pentaCBs reduce thyroid hormone levels in rats, suggesting that
the metabolites may act as endocrine-disrupters.
ARTICLES
Reduction of thyroid hormone levels by methylsulfonyl metabolites of tetra- and pentachlorinated biphenyls in male Sprague-Dawley rats
School of Pharmaceutical Sciences, University of Shizuoka, Japan. kato@ys7.u-shizuoka-ken.ac.jp
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Kato, K. Haraguchi, T. Yamazaki, R. Kimura, N. Koga, S. Yamada, and M. Degawa THE DECREASE IN LEVEL OF SERUM THYROXINE BY 2,2',4,5,5'-PENTACHLOROBIPHENYL IN RATS AND MICE: NO CORRELATION WITH FORMATION OF METHYLSULFONYL METABOLITES Drug Metab. Dispos., November 1, 2005; 33(11): 1661 - 1665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Haraguchi, N. Koga, and Y. Kato COMPARATIVE METABOLISM OF POLYCHLORINATED BIPHENYLS AND TISSUE DISTRIBUTION OF PERSISTENT METABOLITES IN RATS, HAMSTERS, AND GUINEA PIGS Drug Metab. Dispos., March 1, 2005; 33(3): 373 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-J. Shin, S.-H. Kim, D. Kim, Y.-H. Kim, H.-W. Lee, Y.-S. Chang, M.-B. Gu, S. H. Ryu, and P.-G. Suh 2,2',4,6,6'-Pentachlorobiphenyl Induces Mitotic Arrest and p53 Activation Toxicol. Sci., April 1, 2004; 78(2): 215 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kato, K. Haraguchi, T. Yamazaki, Y. Ito, S. Miyajima, K. Nemoto, N. Koga, R. Kimura, and M. Degawa Effects of Polychlorinated Biphenyls, Kanechlor-500, on Serum Thyroid Hormone Levels in Rats and Mice Toxicol. Sci., April 1, 2003; 72(2): 235 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Letcher, J. G. Lemmen, B. van der Burg, A. Brouwer, A. Bergman, J. P. Giesy, and M. van den Berg In Vitro Antiestrogenic Effects of Aryl Methyl Sulfone Metabolites of Polychlorinated Biphenyls and 2,2-Bis(4-chlorophenyl)-1,1-dichloroethene on 17{beta}-Estradiol-Induced Gene Expression in Several Bioassay Systems Toxicol. Sci., October 1, 2002; 69(2): 362 - 372. [Abstract] [Full Text] [PDF]
|
|