Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by COURTNEY, K. D.
Right arrow Articles by ANDREWS, J. E.
Right arrow Search for Related Content
PubMed
Right arrow Articles by COURTNEY, K. D.
Right arrow Articles by ANDREWS, J. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1985 Oxford University Press

research-article

Neonatal and Maternal Body Burdens of Hexachlorobenzene (HCB) in Mice: Gestational Exposure and Lactational Transfer1

K. DIANE COURTNEY and JAMES E. ANDREWS

Toxicology Branch, Inhalation Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency Research Triangle Park, North Carolina 27711

Neonatal and Maternal Body Burdens of Hexachlorobenzene (HCB) in Mice: Gestational Exposure and Lactational Transfer. COURTNEY, K. D., and ANDREWS, J. E. (1985). Fundam. Appl. Toxicol. 5, 265–277. Hexachlorobenzene (HCB), a ubiquitous lipophilic pollutant, was readily transferred in the milk of lactating dams to their suckling neonates. Pregnant CD-1 mice were treated during gestation, and the body burdens of HCB in the neonates and the dams were determined during lactation. Also, neonates from dams treated with HCB during gestation were cross-fostered at birth to dams treated with corn oil during gestation. The body burdens of HCB were greater in the neonates exposed to HCB by lactational transfer than the neonates exposed only by gestational transfer. In many tissues, the concentration of HCB in the pups from full litters was similar to that in pups from litters reduced to two pups per litter. Lactational transfer of HCB from the dams to the pups was a major route of excretion in that 95% of HCB was depleted during 20 days of lactation. HCB depletion was similar in dams with whole litters, and those with litters reduced to two pups.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.