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© 1985 Oxford University Press

research-article

Pharmacokinetics of Inhaled Methyl Chloride (CH3Cl) in Male Volunteers1

R. J. NOLAN2, D. L. RICK, T. D. LANDRY, L. P. MCCARTY, G. L. AGIN{dagger} and J. H. SAUNDERS

{dagger}Systems Research Laboratory, The Dow Chemical Company U.S.A., Midland, Michigan 48640 Toxicology Research Laboratory, Health and Environmental Sciences U.S.A., Midland, Michigan 48640

Pharmacokinetics of Inhaled Methyl Chloride (CH3Cl) in Male Volunteers. Nolan, R. J., RICK, D. L., LANDRY, T. D., MCCARTY, L. P., AGIN, G. L., and SAUNDERS, J. H. (1985). Fundam. Appl. Toxicol. 5, 361–369. Six volunteers, 25–41 years of age, were exposed for 6 hr on separate days to 50 and 10 ppm of CH3Cl. Blood and expired air CH3Cl concentrations reached an apparent plateau during the first hour of the exposure and were proportional to the exposure concentration. Consistent with previous reports, the volunteers could be separated into two discrete groups based on the differences observed in their blood and expired air CH3Cl concentrations. Both groups eliminated CH3Cl rapidly once the exposure was terminated, but CH3Cl was eliminated more rapidly by those volunteers with the lower blood and expired air CH3Cl concentrations. The existence of these two groups can be explained by a twofold difference in the rate at which they metabolized CH3Cl; however, this difference is of questionable toxicological significance. Urinary excretion of the putative metabolite S-methyl cysteine was not related to the exposure; thus, it is not a valid means of monitoring occupational exposure to CH3Cl.


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