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© 1985 Oxford University Press

research-article

Monochlorodiisobutylene Vapor: Acute and 9-Day Inhalation Studies in Fischer-344 Rats and B6C3F1 Mice1

WILLIAM M. SNELLINGS2, DAROL E. DODD, HAROLD C. GRICE*,3 and RICHARD D. PHILLIPS{dagger}

*Polysar Ltd. Sarnia, Ontario, Canada {dagger}Exxon Corporation, Research and Environmental Health Division East Millstone, New Jersey 08873 Bushy Run Research Center Export, Pennsylvania 15632

Monochlorodiisobutylene Vapor Acute and 9-Day Inhalation Studies in Fischer-344 Rats and B6C3F1 Mice. SNELUNGS, W. M., DODD, D. E., GRICE, H. C, AND PHILLIPS, R. D. (1985) Fundam. Appl. Toxicol. 5, 506–514. Acute and 9-day repeated exposures to monochlorodiisobutylene (CDIB) were conducted in male and female Fischer-344 rats and B6C3F1 mice. The 4-hr LC50 values for these animals ranged between 1400 and 2100 ppm. Animals in the 9-day study were exposed at a mean concentration of 478, 97, or 25 ppm of CDIB for 6 hr per day. Treatment-related effects differed between species in this study. Body weight change was decreased in rats. Morphologic changes in the kidneys with accompanying polyuria and hematuria/hemoglobinuria were observed in male rats. The only effect observed at 25 ppm was a low incidence of hematuria/hemoglobinuria in male rats. Mice appeared unaffected by exposure to CDIB at levels as high as 478 ppm


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