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© 1985 Oxford University Press

research-article

Studies on Reproduction in Rats with Meclofenamate Sodium, a Nonsteroidal Anti-inflammatory Agent

JUDITH A. PETRERE, RONALD R. HUMPHREY, JOHN A. ANDERSON, JAMES E. FITZGERALD and FELIX A. DE LA IGLESIA

Wamer-Lamben/Parke-Davis, Pharmaceutical Research Ann Arbor, Michigan 48105

Studies on Reproduction in Rats with Meclofenamate Sodium, a Nonsteroidal Anti-inflammatory Agent. PETRERE, J. A., HUMPHREY, R. R., ANDERSON, J. A., FITZGERALD, J. E., AND DE LA IGLESIA, F. A. (1985). Fundam. Appl. Toxicol. 5, 665–671. Reproduction and teratology studies were performed in rats given meclofenamate sodium, a nonsteroidal anti-inflammatory agent. Dosages of 0, 3, 6, and 9 mg/kg were administered orally as dietary admixtures in the Fertility and Perinatal-Postnatal studies. In the Teratology study, dosages of 10, 12, 15, and 20 mg/kg were administered by intragastric intubation. In the Male-Fertility study no adverse effects on fertility or litter and offspring parameters were observed in two generations. In the Female-Fertility and Perinatal-Postnatal studies, maternal toxicity (death associated with intestinal ulceration and adhesions) was particularly evident during lactation. Prolonged gestation periods, decreased weanling weights, and increased weanling mortality were evident at dosages of 6 and 9 mg/kg. Increased postimplantation loss occurred at 6 and 9 mg/kg in the Term Sacrifice subgroup of the Female-Fertility study. Fertility rates were unaffected and all other litter and offspring parameters of the F1 and F2 generations appeared normal. In the Teratology study no adverse effects on embryonic or fetal development were evident at maternally toxic dosages up to 20 mg/kg. © 1985 Society of Texicology.


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