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© 1985 Oxford University Press

research-article

Effects of ClO2 on the Absorption and Distribution of Dietary Iodide in the Rat

ROBERT M. HARRINGTON*, HOWARD G. SHERTZER* and J. PETER BERCZ{dagger},1

*Department of Environmental Health, University of Cincinnati Medical Center Cincinnati, Ohio 45267-0056 {dagger}U.S. Environmental Protection Agency, Health Effects Research Laboratory, Toxicology and Microbiology Division Cincinnati, Ohio 45268

Effects of ClO2 on the Absorption and Distribution of Dietary Iodide in the Rat HARRINGTON, R. M., SHERTZER, H. G., AND BERCZ, J. P. (1985). Fundam. Appl. Toxicol. 5, 672–678. Aqueous chlorine dioxide (ClO2g), an alternative disinfectant for drinking water, was found to decrease gastrointestinal (GI) bioavailability of dietary iodide. It has been previously reported that subchronic exposure to ClO2 decreases thyroxine (T4) levels in nonhuman primates. In this study in vitro experiments with animal feed, isolated rat stomachs, as well as in vivo studies with intact rats, showed that ClO2 in drinking water (at in situ concentrations as low as 2 ppm) oxidizes iodide to its reactive elemental (radical) state, binding it to organic substances present in the GI tract. A single instance of acute exposure to ClO2, however, did not decrease blood iodide levels, or thyroid glandular uptake of iodine


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