Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Saillenfait, A. M.
Right arrow Articles by Fabries, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saillenfait, A. M.
Right arrow Articles by Fabries, J. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Toxicological Sciences, Vol 50, 136-145, Copyright © 1999 by Society of Toxicology

ARTICLES

Developmental toxicities of methacrylic acid, ethyl methacrylate, n- butyl methacrylate, and allyl methacrylate in rats following inhalation exposure

AM Saillenfait, P Bonnet, F Gallissot, A Peltier and JF Fabries
Institut National de Recherche et de Securite, Vandoeuvre, France. saillenfait@inrs.fr

The developmental toxicities of 4 methacrylates were studied in Sprague- Dawley rats after inhalation exposure for 6 h/day, during days 6 to 20 of gestation. The exposure concentrations were, for methacrylic acid, 0, 50, 100, 200, or 300 ppm; for ethyl methacrylate, 0, 600, 1200, 1800, or 2400 ppm; for n-butyl methacrylate, 0, 100, 300, 600, or 1200 ppm; and for allyl methacrylate, 0, 12, 25, 50, or 100 ppm. No significant increases in embryo/fetal lethality or fetal malformations were observed after exposure to any of these methacrylates. Fetal toxicity evidenced by statistically significant decreases in fetal body weights was observed at exposure levels > or = 1200 ppm ethyl methacrylate, > or = 600 ppm n-butyl methacrylate, and at 100 ppm allyl methacrylate. Statistically significant increases in the incidence of fetuses with skeletal variations and of fetuses with any variations were noted at 1200 ppm n-butyl methacrylate. These developmental effects were observed in the presence of overt signs of maternal toxicity. While maternal toxicity was observed, methacrylic acid caused no evidence of developmental toxicity up to 300 ppm.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 International Journal of ToxicologyHome page
Final Report of the Safety Assessment of Methacrylic Acid
International Journal of Toxicology, September 1, 2005; 24(5_suppl): 33 - 51.
[Abstract] [Full Text] [PDF]

Home page
 International Journal of ToxicologyHome page
Final Report of the Safety Assessment of Methacrylate Ester Monomers Used in Nail Enhancement Products
International Journal of Toxicology, September 1, 2005; 24(5_suppl): 53 - 100.
[Abstract] [Full Text] [PDF]

Home page
 International Journal of ToxicologyHome page
Amended Final Report on the Safety Assessment of Ethyl Methacrylate
International Journal of Toxicology, April 1, 2002; 21(1_suppl): 63 - 79.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.