Toxicological Sciences, Vol 50, 136-145, Copyright © 1999 by Society of Toxicology
AM Saillenfait, P Bonnet, F Gallissot, A Peltier and JF Fabries
The developmental toxicities of 4 methacrylates were studied in Sprague-
Dawley rats after inhalation exposure for 6 h/day, during days 6 to 20 of
gestation. The exposure concentrations were, for methacrylic acid, 0, 50,
100, 200, or 300 ppm; for ethyl methacrylate, 0, 600, 1200, 1800, or 2400
ppm; for n-butyl methacrylate, 0, 100, 300, 600, or 1200 ppm; and for allyl
methacrylate, 0, 12, 25, 50, or 100 ppm. No significant increases in
embryo/fetal lethality or fetal malformations were observed after exposure
to any of these methacrylates. Fetal toxicity evidenced by statistically
significant decreases in fetal body weights was observed at exposure levels
> or = 1200 ppm ethyl methacrylate, > or = 600 ppm n-butyl
methacrylate, and at 100 ppm allyl methacrylate. Statistically significant
increases in the incidence of fetuses with skeletal variations and of
fetuses with any variations were noted at 1200 ppm n-butyl methacrylate.
These developmental effects were observed in the presence of overt signs of
maternal toxicity. While maternal toxicity was observed, methacrylic acid
caused no evidence of developmental toxicity up to 300 ppm.
ARTICLES
Developmental toxicities of methacrylic acid, ethyl methacrylate, n- butyl methacrylate, and allyl methacrylate in rats following inhalation exposure
Institut National de Recherche et de Securite, Vandoeuvre, France. saillenfait@inrs.fr
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