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Toxicological Sciences, Vol 50, 54-63, Copyright © 1999 by Society of Toxicology

ARTICLES

Polychlorinated biphenyls (PCBs) selectively disrupt serotonergic cell growth in the developing Spisula embryo

CR Smith, CM Barker, LF Barker, K Jessen-Eller and CL Reinisch
Department of Environmental and Population Health, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536, USA.

Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that exert neurotoxic effects during embryonic development. The present study demonstrates that early embryonic exposure to a mixture of PCBs (Aroclor 1254) results in a decrease in serotonergic cell growth. Using a novel, marine invertebrate embryo model, Spisula solidissima, immunocytochemistry, and confocal microscopy techniques, a dose-dependent decrease in serotonergic cell number was quantified within 24 h of exposure. This effect was seen with doses as low as 1 ppm Aroclor 1254. These findings demonstrate that environmentally relevant doses of Aroclor 1254 impair development of the serotonergic nervous system.
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