Toxicological Sciences, Vol 52, 111-117, Copyright © 1999 by Society of Toxicology
H Mukhtar and N Ahmad
The concept of prevention of cancer using naturally occurring substances
that could be included in the diet consumed by the human population is
gaining increasing attention. Tea, next to water, is the most popularly
consumed beverage in the world and it is grown in about 30 countries.
Abundant data, amassed from several laboratories around the world in the
last ten years, provided convincing evidence that polyphenolic antioxidants
present in tea afford protection against cancer risk in many animal-tumor
bioassay systems. The epidemiological studies, though inconclusive, have
also suggested that the consumption of tea is associated with a lowered
risk of cancer. Much of this work has been done on green tea; less is known
about black tea. Green tea contains many polyphenolic antioxidants, and
(-)-epigallocatechin-3- gallate (EGCG) is the key polyphenolic antioxidant
believed to be responsible for most of the cancer chemopreventive
properties of green tea. This review will discuss these effects and the
molecular mechanisms associated with the biological response to green-tea
polyphenols.
ARTICLES
Green tea in chemoprevention of cancer
Department of Dermatology, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106, USA. hxm4@po.cwru.edu
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Guo, S. Yang, C. Taylor, and G. E. Sonenshein Green Tea Polyphenol Epigallocatechin-3 Gallate (EGCG) Affects Gene Expression of Breast Cancer Cells Transformed by the Carcinogen 7,12-Dimethylbenz[a]Anthracene J. Nutr., December 1, 2005; 135(12): 2978S - 2986S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Hou, S. Sang, H. You, M.-J. Lee, J. Hong, K.-V. Chin, and C. S. Yang Mechanism of Action of (-)-Epigallocatechin-3-Gallate: Auto-oxidation-Dependent Inactivation of Epidermal Growth Factor Receptor and Direct Effects on Growth Inhibition in Human Esophageal Cancer KYSE 150 Cells Cancer Res., September 1, 2005; 65(17): 8049 - 8056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Aktas, T. Prozorovski, A. Smorodchenko, N. E. Savaskan, R. Lauster, P.-M. Kloetzel, C. Infante-Duarte, S. Brocke, and F. Zipp Green Tea Epigallocatechin-3-Gallate Mediates T Cellular NF-{kappa}B Inhibition and Exerts Neuroprotection in Autoimmune Encephalomyelitis J. Immunol., November 1, 2004; 173(9): 5794 - 5800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Fassina, R. Vene, M. Morini, S. Minghelli, R. Benelli, D. M. Noonan, and A. Albini Mechanisms of Inhibition of Tumor Angiogenesis and Vascular Tumor Growth by Epigallocatechin-3-Gallate Clin. Cancer Res., July 15, 2004; 10(14): 4865 - 4873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Kundu, H.-K. Na, K.-S. Chun, Y.-K. Kim, S. J. Lee, S. S. Lee, O.-S. Lee, Y.-C. Sim, and Y.-J. Surh Inhibition of Phorbol Ester-Induced COX-2 Expression by Epigallocatechin Gallate in Mouse Skin and Cultured Human Mammary Epithelial Cells J. Nutr., November 1, 2003; 133(11): 3805S - 3810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Arab and D. Il'yasova The Epidemiology of Tea Consumption and Colorectal Cancer Incidence J. Nutr., October 1, 2003; 133(10): 3310S - 3318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Hasler Functional Foods: Benefits, Concerns and Challenges--A Position Paper from the American Council on Science and Health J. Nutr., December 1, 2002; 132(12): 3772 - 3781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M Buetler, M. Renard, E. A Offord, H. Schneider, and U. T Ruegg Green tea extract decreases muscle necrosis in mdx mice and protects against reactive oxygen species Am. J. Clinical Nutrition, April 1, 2002; 75(4): 749 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Adcocks, P. Collin, and D. J. Buttle Catechins from Green Tea (Camellia sinensis) Inhibit Bovine and Human Cartilage Proteoglycan and Type II Collagen Degradation In Vitro J. Nutr., March 1, 2002; 132(3): 341 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lamy, D. Gingras, and R. Beliveau Green Tea Catechins Inhibit Vascular Endothelial Growth Factor Receptor Phosphorylation Cancer Res., January 1, 2002; 62(2): 381 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Allen, L. Mueller, S. N. Williams, L. C. Quattrochi, and J. Raucy The Use of a High-Volume Screening Procedure to Assess the Effects of Dietary Flavonoids on Human CYP1A1 Expression Drug Metab. Dispos., August 1, 2001; 29(8): 1074 - 1079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Meng, M.-J. Lee, C. Li, S. Sheng, N. Zhu, S. Sang, C.-T. Ho, and C. S. Yang Formation and Identification of 4'-O-Methyl-(-)-Epigallocatechin in Humans Drug Metab. Dispos., June 1, 2001; 29(6): 789 - 793. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Brown, T. Byers, K. Thompson, B. Eldridge, C. Doyle, A. M. Williams, and American Cancer Society Workgroup on Nutrition and Nutrition During and After Cancer Treatment: A Guide for Informed Choices by Cancer Survivors CA Cancer J Clin, May 1, 2001; 51(3): 153 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Balasubramanian, T. Efimova, and R. L. Eckert Green Tea Polyphenol Stimulates a Ras, MEKK1, MEK3, and p38 Cascade to Increase Activator Protein 1 Factor-dependent Involucrin Gene Expression in Normal Human Keratinocytes J. Biol. Chem., January 11, 2002; 277(3): 1828 - 1836. [Abstract] [Full Text] [PDF]
|
|