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Toxicological Sciences, Vol 52, 127-146, Copyright © 1999 by Society of Toxicology


ARTICLES

Dietary fat and breast cancer

WC Willett
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02130, USA. dosulliv@sph.harvard.edu

Good reasons exist to reduce intake of animal and partially hydrogenated fat. Existing data, however, provide little support for the hypothesis that reduction in dietary fat composition, even to 20% of energy during adulthood, will lead to a substantial reduction in breast cancer in Western cultures. Some evidence suggests that substituting monounsaturated fat for other sources of energy may even reduce risk of breast cancer; this deserves further examination. Also, the avoidance of weight gain during adulthood has many benefits, which are likely to include an important reduction in risk of postmenopausal breast cancer.
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