Toxicological Sciences, Vol 52, 95-100, Copyright © 1999 by Society of Toxicology
GD Stoner, LA Kresty, PS Carlton, JC Siglin and MA Morse
A group of arylalkyl isothiocyanates were tested for their abilities to
inhibit tumorigenicity and DNA methylation induced by the esophageal-
specific carcinogen, N-nitrosomethylbenzylamine (NMBA) in the F344 rat
esophagus. Phenylpropyl isothiocyanate (PPITC) was more potent than either
phenylethyl isothiocyanate (PEITC) or benzyl isothiocyanate (BITC).
Phenylbutyl isothiocyanate (PBITC), however, had a lesser inhibitory effect
on esophageal tumorigenesis, and phenylhexyl isothiocyanate (PHITC)
actually enhanced esophageal tumorigenesis. Thus, the two- and three-carbon
isothiocyanates were more effective inhibitors of NMBA-esophageal
carcinogenesis than the longer chain isothiocyanates. The effects of the
isothiocyanates on tumorigenesis were well correlated as to their effects
on DNA adduct formation. The most likely mechanism of inhibition of
tumorigenesis by these isothiocyanates is via inhibition of the cytochrome
P450 enzymes responsible for the metabolic activation of NMBA in rat
esophagus. A freeze-dried strawberry preparation was also evaluated for its
ability to inhibit NMBA-esophageal tumorigenesis. It proved to be an
effective inhibitor, although not as potent as either PEITC or PPITC. The
inhibitory effect of the berries could not be attributed solely to the
content of the chemopreventive agent, ellagic acid, in the berries.
ARTICLES
Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer
Division of Environmental Health Sciences, The Ohio State University School of Public Health, and The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA. stoner.21@osu.edu
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