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Toxicological Sciences, Vol 52, 107-110, Copyright © 1999 by Society of Toxicology

ARTICLES

Conjugated linoleic acid and the control of cancer and obesity

M Pariza, Y Park and M Cook
Food Research Institute, Department of Food Microbiology and Toxicology, University of Wisconsin-Madison, 1925 Willow Drive, Madison, WI 53706-1187, USA; Corresponding author; Fax: (608) 263 1114; E-mail: mwpariza@facstaff.wisc.edu

The effects of conjugated linoleic acid (CLA) in animals are reviewed. In most of the CLA preparations that have been investigated to date for biological activity, two CLA isomers are present in about equal concentrations: <it>cis-9,trans-11 CLA, and <it>trans-10,cis-12 CLA. The occurrence of these isomers in foods and their production by rumen microorganisms are discussed. Potential mechanisms of action as regards the effects of CLA on cancer and body composition are reviewed, including recent evidence that body composition changes are produced by the <it>trans-10,<it>cis</it>-12 CLA isomer. Evidence is presented indicating that CLA may modulate cellular response to tumor necrosis factor-alpha (TNF-<IMG SRC="/math/alpha.gif">). The mechanistic implications of this finding are considered.Keywords: conjugated linoleic acid; body composition; cytokines; tumor necrosis factor-<IMG SRC="/math/alpha.gif">
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