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© 1986 Oxford University Press

research-article

Evidence of Necrosis in Human Intercostal Muscle following Inhalation of an Organophosphate Insecticide

LYNN WECKER*,{dagger}, ROBERT E. MARK{dagger} and WOLF-D. DETTBARN{dagger}

*Department of Pharmacology, Louisiana State University Medical Center New Orleans, Louisiana 70112 {dagger}Department of Pharmacology and Pathology and the Jerry Lewis Neuromuscular Disease Research Center, Vanderbilt University School of Medicine Nashville, Tennessee 37232

Evidence of Necrosis in Human Intercostal Muscle following Inhalation of an Organophosphate Insecticide. WECKER, L, MRAK R. E., AND DETTBARN, W-D. (1986). Fundam Appl. Toxicol. 6, 172–174. Intercostal muscle samples obtained from autopsy of a 51-year-old male exposed to an organophosphate insecticide were analyzed for cholinesterase activity and muscle fiber integrity. Muscle cholinesterase activity, 5 days after exposure, was reduced to 53% of control values. Histological analysis indicated the presence of muscle fibers with subsarcolemmal grouped granular basophilic inclusions and scattered necrotic fibers. Results indicate that acute organophosphate exposure through inhalation can lead to skeletal muscle fiber damage in humans, similar to results obtained by ingestion. Furthermore, the pathology is comparable to the histological alterations observed in rats following acute injection of organophosphates.


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