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© 1986 Oxford University Press

research-article

Prophylactic Action of Hexamethonium, Trimethaphan, and Mecamylamine against Diisopropyl Fluorophosphate Poisoning in Mice

GEORGE C. Y. CHIOU1, WALTER T. S. CHANG and TACHIO AIMOTO

Department of Medical Pharmacology & Toxicology, Texas A&M University College of Medicine Texas 77843

Prophylactic Action of Hexamethonium, Trimethaphan, and Mecamylamine against Diisopropyl Fluorophosphate Poisoning in Mice. CHIOU, G. C. Y., CHANG, W. T. S., AND AIMOTO, T. (1986). Fund. Appl. Toxicol. 6, 35–43. Hexamethonium, trimethaphan, and mecamylamine are ganglionic blockers which can reduce acetylcholine (ACh) release presynaptically. All these agents are capable of protecting mice from diisopropyl fluorophosphate (DFP) intoxication by prolonging the latent period of death or by completely preventing death. Combinations of these agents with 2-pyridine aldoxime methochioride (2-PAM) (50 mg/kg) improved prophylactic action even further. These results indicate that reduction of ACh release presynaptically plus neutralization of organophosphates with 2-PAM could be an effective way to reduce mortality in patients exposed to organophosphorus poisons.


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