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© 1986 Oxford University Press

research-article

Long-Term Toxicity of Octachlorostyrene in the Rat

I. CHU*, D. C. VILLENEUVE*, V. E. SECOURS*, V. E. VALLI{dagger}, S. LEESON{ddagger} and S. Y. SHEN§

*Environmental and Occupational Toxicology Division, Bureau of Chemical Hazards. Environmental Health Directorate Ottawa,Ontario KIA 0L2, Canada {dagger}Biopath Analysis Limited Guelph, Ontario NIE 2X7, Canada {ddagger}Department of Animal Poultry, University of Guelph Guelph, Ontario NIG 2W1, Canada §Department of Public Health, Shanxi Medical College Taiyuan, The People's Republic of China

Long-Term Toxicity of Octachlorostyrene in the Rat. CHU, I., VILLENEUVE, D. C., SECOURS, V. E., VALLI, V. E., LEESON, S., AND SHEN, S. Y. (1986). Fundam. Appl. Toxicol. 6, 69–77. This study was designed to investigate the toxic effects produced by the long-term exposure to octachlorostyrene (OCS), a demonstrated environmental contaminant in the Great Lakes region of North America and the Norwegian Coast in Europe. Groups of 20 male and 20 female rats were administered OCS in diets at 0.005, 0.05, 0.5, 5.0, or 50 ppm for 12 months. Weight gain and food consumption were not affected. Increased liver weights were observed in the groups fed the highest dose of OCS. Hepatic microsomal aniline hydroxylase and aminopyrine demethylase activities were induced in male rats fed 5.0 ppm OCS and higher and in female rats fed 50 ppm of the chemical. Elevated serum cholesterol levels were seen in rats of both sexes fed the highest dose. Treatment-related histological changes occurred in the thyroid, liver, and kidney of rats A dose-dependent accumulation of OCS in the fat and liver of the rats was found. Based on the data presented, it was concluded that the no adverse effect level of OCS was 0.5 ppm.


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