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© 1986 Oxford University Press

research-article

Genotoxic Properties of Haloacetonitriles: Drinking Water By-Products of Chlorine Disinfection1

F. B. DANIEL2, K. M. SCHENCK, J. K. MATTOX, E. L. C. LIN, D. L. HAAS and M. A. PEREIRA

Health Effects Research Laboratory, U.S. Environmental Protection Agency 26 West St. Clair Street, Cincinnati, Ohio 45268

Genotoxic Properties of Haloacetonitriles: Drinking Water By-Products of Chlorine Disinfection. DANIEL, F. B., SCHENCK, K. M., MATTOX, J. K., LIN, E. L. C., HAAS, D. L., AND PEREIRA, M. A. (1986). Fundam. Appl. Toxicol. 6,447–453. Chlorinated and brominated haloacetonitriles (HAN), known drinking water contaminants which form during chlorine disinfection, were investigated for genotoxic activity. The HAN produced DNA strand breaks in cultured human lymphoblastic (CCRF-CEM) cells, bound to the nucleophilic trapping agent 4-(p-nitrobenzyl)pyridine and formed a covalent bond to polyadenylic acid in a cell-free reaction system. Thus, we have demonstrated that these chemicals are genotoxic, which would indicate a potential for carcinogenic activity and for human health hazard.


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