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© 1986 Oxford University Press

research-article

The Effects of Inhalation of Organic Chemical Air Contaminants on Murine Lung Host Defenses1

CATHERINE ARANYI*,2, WILLIAM J. O'SHEA*, JUDITH A. GRAHAM{dagger} and FREDERICK J. MILLER{dagger}

*IIT Research Institute, Life Sciences Research Department 10 West 35th Street. Chicago, Illinois 60616 {dagger}Toxicology Branch, Health Effects Research Laboratory, U.S. EPA Research Triangle Park North Carolina 27711

The Effects of Inhalation of Organic Chemical Air Contaminants on Murine Lung Host Defenses. ARANYI, C., O'SHEA, W. J., GRAHAM, J. A., AND MILLER, F. J. (1986). Fundam. Appl. Toxicol. 6,713–720. The potential health hazards of exposure to threshold limit value (TLV) concentrations of acetaldehyde, acrolein, propylene oxide, chloroform, methyl chloroform, carbon tetrachioride, allyl chloride, methylene chloride, ethylene trichloride, perchloroethylene, benzene, phenol, monochlorobenzene, and benzyl chloride, compounds which may be present in the ambient or work room atmosphere were investigated. The effects of single and multiple 3-hr inhalation exposures were evaluated in mice by monitoring changes in their susceptibility to experimentally induced streptococcus aerosol infection and pulmonary bactericidal activity to inhaled Klebsiella pneumoniae. When significant changes in these parameters were found, further exposures were performed at reduced vapor concentrations until the no-measurable-effect level was reached. Multiple exposures on 5 consecutive days were then performed at this concentration. Significant increases in susceptibility to respiratory streptococcus infection were observed after single 3-hr exposure to TLV concentrations of methylene chloride, perchloroethylene, and ethylene trichloride. For methylene chloride and perchioroethylene, these exposure conditions also resulted in significantly decreased pulmonary bactericidal activity.


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