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Toxicological Sciences 64, 1-3 (2001)
Copyright © 2001 by the Society of Toxicology

TOXICOLOGICAL HIGHLIGHT

Toxicant-Induced Oxidative Stress in Cancer

Brad L. Upham*,{dagger},1 and James G. Wagner*,{ddagger}

* National Food Safety and Toxicology Center, {dagger} Department of Pediatrics and Human Development, and {ddagger} Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan 48824-1317

ABSTRACT

The article highlighted in this issue is "The Role of Oxidative Stress in Indium Phosphide-Induced Lung Carcinogenesis in Rats" by Barbara C. Gottschling, Robert R. Maronpot, James R. Hailey, Shyamal Peddada, Cindy R. Moomaw, James E. Klaunig, and Abraham Nyska (pp. 28–40). The article integrates a traditional pathologic study of toxicant-induced pulmonary carcinogenesis with an immunohistologic assessment of oxidative stress, thereby determining a potential mechanism of action of a toxicant, specifically indium phosphide.


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