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© 1986 Oxford University Press

research-article

Acute Toxicity of Petroleum- and Shale-Derived Distillate Fuel, Marine: Light Microscopic, Hematologic, and Serum Chemistry Studies1

GEORGE A. PARKER*, VICTOR BOGO{dagger},2 and ROBERT W. YOUNG{dagger}

* P O Box 350, Great Falls, Virgina 22066 {dagger}Behavorial Sciences Department, Armed Forces Radiobiology Research Institute Bethesda, Maryland 20814-5145

Acute Toxicity of Petroleum- and Shale-Derived Distillate Fuel, Marine: Light Microscopic, Hematologic, and Serum Chemistry Studies. Parker, G. A., Bogo, V., and Young, R. W. (1986). Fundam. Appl. Toxicol. 7, 101-105. Rats were gavaged with 60, 48, 38, 30, or 24 ml/kg of either petroleum (P) or shale (S)-derived distillate fuel, marine (DFM). Surviving rats were killed 14 days after dosing. There was a slight difference in toxicity of the two fuels but neither fuel was very toxic. The LD50/14 was 43 ml/kg for P-DFM and 50 ml/kg for S-DFM. Lesions in rats that died indicated hepatic and renal toxicity. In another study, rats were gavaged with 24 ml/kg of either P- or S-DFM and killed at 1,2, or 3 days after dosing. Prominent clinicopathologic findings included loss of body weight, hematologic evidence of dehydration, transient leukopenia, and serum chemistry and histopathologic alterations indicative of mild hepatic and renal toxicity.


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