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© 1986 Oxford University Press

research-article

The Influence of Recombinant DNA-Derived Human and Murine Gamma Interferons on Mouse Hepatic Drug Metabolism

MICHAEL R. FRANKLIN and BRYAN S. FINKLE

Department of Biochmical Pharmacology and Toxicology, University of Utah Salt Lake City, Utah 84112

The Influence of Recombinant DNA-Derived Human and Murine Gamma Interferons on Mouse Hepatic Drug Metabolism. FRANKLIN, M. R., AND FINKLE, B. S. (1986) Fundam. Appl Toxicol. 7, 165-169. Human gamma interferon given for up to 5 days by subcutaneous infusion or intraperitoneal injection did not significantly alter mouse hepatic microsomal oxidative drug-metabolizing enzyme activities. In contrast, murine gamma interferon and human alpha interferon given for 5 days at the same dose (107 units/kg) caused 25 and 50% decreases, respectively, in hepatic microsomal cytochrome P-450 concentrations. The human alpha interferon-induced decline in cytochrome P-450 was accompanied by a significant drop in p-vnitroanisole demethylase activity and significant elevations in serum alanine aminotransferase and cytosolic glutathione S-transferase activities. An elevation in glutathione-5-transferase was the only significant change found following human gamma interferon administration. Microsomal UDP-glucuronosyltrans-ferase activity was unaffected by any interferon.


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