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© 1986 Oxford University Press

research-article

A Subchronic, Teratologic, and Dominant Lethal Study of 2-Methylresorcinol in Rats

II. Teratologic and Dominant Lethal Study

THOMAS A. RE1, RICHARD F. LOEHR*, STEPHEN C. RODRIGUEZ*, DEAN E. RODWELL{dagger} and CLYDE M. BURNETT*

*Clairol Research Laboratories 2 Blachley Road, Stamford, Connecticut 06922 {dagger}WIL Research Laboratories Inc., 1407 Montgomery Township Road 805, Ashland, Ohio 44805

A Subchronic, Teratologic, and Dominant Lethal Study of 2-Methylresorcinol in Rats. II. Teratologic and Dominant Lethal Study. RE, T.A., LOEHR, R.F., RODRIGUEZ, S.C, ROD-WELL, D.E., AND BURNETT, C.M. (1986). Fundam. Appl. Toxicol. 7, 293-298. 2-Methylresorcinol (2-MR) was administered to groups of 40 male and 35 female Sprague-Dawley rats by admixture with the diets at levels of 0.1, 0.4, and 1.5% (see Part I; T.H. Re, R.F. Loehr, S.C. Rodriguez, C.E. Gilmore, and C.M. Burnett, 1986, Fundam. Appl. Toxicol. 7, 287-292). Following 90 days of exposure, 25 randomly selected females in each group were mated to untreated males in a teratology study in which exposure to 2-MR continued throughout the gestation period. After 20 weeks of exposure to 2-MR, 20 males per group were removed from the test diets containing 2-MR and were mated to untreated females in a dominant lethal study. Feeding 2-MR at levels of 0.4 and 1.5% in the diet was associated with a significant reduction in body weight gain. 2-MR was not teratogenic nor did it induce a dominant lethal effect under the Conditions of this Study.


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