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Toxicological Sciences 72, 185-187 (2003)
Copyright © 2003 by the Society of Toxicology

TOXICOLOGICAL HIGHLIGHT

From Anticholinesterase Toxicity to Alzheimer’s Disease: Important Interactions of Cholinergic and NMDA Receptor Systems

E. Jon Popke

Safety Pharmacology, Wyeth Research, 641 Ridge Road, Chazy, NY 12921

For correspondence via fax: (518) 846-6383. E-mail: popkej{at}wyeth.com.

ABSTRACT

The article highlighted in this issue is "Dizocilpine Improves Beneficial Effects of Cholinergic Antagonists in Anticholinesterase-Treated Mice," by Andrzej Dekundy, Rafal M. Kaminski, and Waldemar A. Turski (pp. 289–295). It explores the relationship between cholinergic and N-methyl-D-aspartate (NMDA) receptors as mediators of anticholinesterase toxicity. The following review summarizes these findings and discusses their broader implications for central nervous system pharmacology. Alzheimer’s disease is discussed as an example of how knowledge of the interactions between NMDA and cholinergic receptors may lead to a better understanding of human disease.


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