Skip Navigation


ToxSci Advance Access originally published online on June 27, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
74/2/233    most recent
kfg170v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cannon, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cannon, R. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Toxicological Sciences 74, 233-234 (2003)
Copyright © 2003 by the Society of Toxicology

TOXICOLOGICAL HIGHLIGHT

The Tg.AC Mouse Model Passes Test by Failing to Respond

Ronald E. Cannon1

Cancer Biology Group, National Center for Toxicogenomics, NIEHS, Research Triangle Park, North Carolina 27709

ABSTRACT

This issue highlights two companion articles, "Selection of Drugs to Test the Specificity of the Tg.AC Assay by Screening for Induction of the gadd153 Promoter in Vitro" by Karol L. Thompson and Frank D. Sistare (pp. 260–270) and "Evaluation of the Tg.AC Assay: Specificity Testing with Three Noncarcinogenic Pharmaceuticals that Induce Selected Stress Gene Promoters in Vitro and the Inhibitory Effects of Solvent Components" by Karol L. Thompson, Barry A. Rosenzweig, James L. Weaver, Jun Zhang, Karl K. Lin, and Frank D. Sistare (pp. 271–278). These articles outline a unique paradigm for selecting and assaying chemicals for carcinogenic activity using the short-term in vivo Tg.AC mouse model. This Tg.AC mouse model was the primary focus of the work; however, the strategy employed could be exploited for the other alternative mouse models.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.