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ToxSci Advance Access originally published online on February 19, 2004
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Toxicological Sciences 79, 4-9 (2004)
Toxicological Sciences vol. 79 no. 1 © Society of Toxicology; all rights reserved.

FORUM

Workshop Overview: Hepatotoxicity Assessment for Botanical Dietary Supplements

Kristine L. Willett*,1, Robert A. Roth{dagger} and Larry Walker{ddagger}

* Department of Pharmacology and Environmental Toxicology, School of Pharmacy, University of Mississippi, University, Mississippi 38677; {dagger} National Center for Food Safety and Toxicology, Michigan State University, East Lansing, Michigan 48824; and {ddagger} National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Mississippi 38677

Received December 6, 2003; accepted January 6, 2004

Botanical dietary supplements (herbal products) have flooded the market in the United States over the past decade, and studies show a significant percentage of Americans use them. With increasing frequency and duration of exposure, some serious adverse effects, though relatively uncommon, have been reported. Among the most troublesome is the association of some botanicals with serious hepatotoxicity. In some cases, hepatotoxicity has been linked to the consumption of botanicals with recognized hepatotoxic components (e.g., pyrrolizidine alkaloids). However, in other cases, the causative agent(s) is less clear and, overall, the mechanisms of hepatotoxicity are poorly understood. To help create a scientific basis for understanding botanical-induced hepatotoxicity and better tools for hepatotoxicity assessment and prediction, the National Center for Natural Product Research (NCNPR) hosted a workshop (September 8 and 9, 2003) in cooperation with the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration (FDA). The workshop featured presentations by 22 experts and was attended by 65 individuals. The agenda can be found in the supplementary data at www.toxsci.oupjournals.org.


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