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© 1987 Oxford University Press

other

Effect of Various Polybrominated Biphenyls on Cell–Cell Communication in Cultured Human Teratocarcinoma Cells

T. J. KAVANAGH1, C.-C. CHANG and J. E. TROSKO

Center for Environmental Toxicology Department of Pediatrics/Human Development Michigan State University East Lansing Michigan 48824

Effect of Various Polybrominated Biphenyls on Cell–Cell Communication in Cultured Human Teratocarcinoma Cells. KAVANAGH, T. J., CHANG, C.-C, and TROSKO, J. E. (1987). Fundam. Appl. Toxicol. 8, 127–131. Firemaster BP-6 (FM), a mixture of polybrominated biphenyls (PBB), and the congeners 2,2',4,4',5,5'-hexabromobiphenyl (245-HBB), 3,3',4,4',5,5'-hexabro-mobiphenyl (345-HBB), and 3,3',4,4'-tetrabromobiphenyl (34-TBB) were tested for their ability to inhibit cell-cell communication between human teratocarcinoma cells in culture. Both FM and 245-HBB were capable of inhibiting cell-cell communication in these cells, with only slight effects on cell survival. 345-HBB was highly cytotoxic, but did not show the ability to interrupt cell-cell communication. 34-TBB was moderately cytotoxic and was also ineffective at blocking cell-cell communication. The results agree with previously published findings in Chinese hamster V79 cells, and are in accordance with proposed structure–activity relationships for these compounds. Inhibition of cell–cell communication, either directly (FM and 245-HBB) or indirectly through necrosis-induced compensatory hyperplasia (345-HBB), may be involved in the promotion of hepatocellular neoplasms by these compounds.


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