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© 1987 Oxford University Press

research-article

A Confirmatory Study of the Up-and-Down Method for Acute Oral Toxicity Testing

ROBERT D. BRUCE

The Procter & Gamble Company, Miami Valley Laboratories P.O. Box 39175, Cincinnati, Ohio 45247

A Confirmatory Study of the Up-and-Down Method for Acute Oral Toxicity Testing. BRUCE, R. D. (1987). Fundam. Appl. Toxicol. 8, 97–100. Ten materials have been tested in parallel both by the "classical" method for acute oral toxicity (LD50) and by the up-and-down method. Materials tested included laundry and dishwashing detergents, a shampoo, a flavor, potassium hydroxide, and caffeine. All testing was done in Sprague–Dawley rats. Excellent agreement was seen between the two methods. The classical method typically used 40 to 50 animals while the up-and-down method required only six to nine animals per material.


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