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© 1987 Oxford University Press

research-article

Five-Month Oral (Diet) Toxicity/lnfectivity Study of Bacillus thuringiensis Insecticides in Sheep

WILLIAM M. HADLEY*, SCOTT W. BURCHIEL*, THOMAS D. MCDOWELL{dagger}, JOHN P. THILSTED{ddagger}, CLAIR M. HIBBS{ddagger}, JERRY A. WHORTON§, PHILLIP W. DAY§, MITCHELL B. FRIEDMAN and RAYMOND E. STOLL#

*College of Pharmacy, School of Medicine, University of New Mexico {dagger}Department of Microbiology, School of Medicine, University of New Mexico {ddagger}NewMexico Veterinary Diagnostic Services, Scientific Laboratory Division, Health and Environment Department 700 Camino De Salud, NE §Animal Resource Facility, School of Medicine, University of New Mexico Albuquerque, New Mexico 87131 Abbott Laboratories North Chicago, Illinois 60064 #Sandoz Research Institute Route 10, East Hanover, New Jersey 07936

Five-Month Oral (Diet) Toxicity/Infectivity Study of Bacillus thuringiensis Insecticides in Sheep. HADLEY, W. M., BURCHIEL, S. W., MCDOWELL, T. D., THILSTED, J. P., HIBBS, C. M., WHORTON, J. A., DAY, P. W., FRIEDMAN, M. B., and STOLL, R. E. (1987). Fundam. Appl. Toxicol. 8, 236–242. Bacillus thuringiensis insecticides (Bt) [Dipel (test substance D or Thuri-cide-HP (test substance T)] were administered in the diet for 5 months to castrated mixed ram-bouillet/merino sheep (24–34 kg at the beginning of the study) at a dose of 500 mg/kg/day (approximately 1012 spores per day). No treatment-related effect was seen on weight gain or clinical chemistry parameters nor were significant gross clinical changes observed. Several blood and tissue samples taken just prior to the time the animals were killed or at necropsy were found to be positive for Bt when cultured. Detailed gross and microscopic pathologic examination of the sheep revealed several incidental lesions. However, the only lesion that may have been associated with the treatment was lymphocytic hyperplasia in Peyer's patches seen in the cecum of three sheep and it was not considered to be clinically significant.


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