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© 1987 Oxford University Press

research-article

The Fate of Inhaled Azodicarbonamide in Rats

J. A. MEWHINNEY, P. H. AYRES, W. E. BECHTOLD, J. S. DUTCHER, Y. S. CHENG, J. A. BOND, M. A. MEDINSKY, R. F. HENDERSON and L. S. BIRNBAUM*

Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute P.O. Box 5890, Albuquerque, New Mexico 87185 *National Institute of Environmental Health Sciences, Research Triangle Park North Carolina 27709

The Fate of Inhaled Azodicarbonamide in Rats. Mewhinney, J. A., AYRES, P. H., BECHTOLD, W. E., DUTCHER, J. S., CHENG, Y. S., BOND, J. A., MEDINSKY, M. A., HENDERSON, R. F., AND BIRNBAUM, L. S. (1987). Fundam. Appl. Toxicol. 8, 372–381. Azodicarbonamide (ADA) is widely used as a blowing agent in the manufacture of expanded foam plastics, as an aging and bleaching agent in flour, and as a bread dough conditioner. Human exposures have been reported during manufacture as well as during use. Groups of male F344/N rats were administered ADA by gavage, by intratracheal instillation, and by inhalation exposure to determine the disposition and modes of excretion of ADA and its metabolites. At 72 hr following gavage, 30% of the administered ADA was absorbed whereas following intratracheal instillation, absorption was 90%. Comparison between groups of rats exposed by inhalation to ADA to achieve body burdens of 24 or 1230 µg showed no significant differences in modes or rates of excretion of [14C]ADA equivalents. ADA was readily converted to biurea under physiological conditions and biurea was the only 14C-labeled compound present in excreta. [14C]ADA equivalents were present in all examined tissues immediately after inhalation exposure, and clearance half-times on the order of 1 day were evident for all tissues investigated. Storage depots for [14C]ADA equivalents were not observed. The rate of buildup of [14C]ADA equivalents in blood was linearly related to the lung content as measured from rats withdrawn at selected times during a 6-hr inhalation exposure at an aerosol concentration of 25 µg, ADA/liter. In a study extending 102 days after exposure, retention of [14C]ADA equivalents in tissues was described by a two-component negative exponential function. The results from this study indicate that upon inhalation, ADA is rapidly converted to biurea and that biurea is then eliminated rapidly from all tissues with the majority of the elimination via the urine.


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