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© 1987 Oxford University Press

research-article

Induction of Epidermal and Hepatic Ornithine Decarboxylase by a Prudhoe Bay Crude Oil

A. D. RAHIMTULA, Y.-Z. LEE and J. SILVA

Biochemistry Department, Memorial University St. John's, Newfoundland, A1B 3X9, Canada

Induction of Epidermal and Hepatic Ornithine Decarboxylase by a Prudhoe Bay Crude Oil. RAHIMTULA, A. D., LEE, Y.-Z. and SILVA, J. (1987). Fundam. Appl. Toxicol. 8, 408–414. Application of a Prudhoe Bay crude oil (PBCO) to the backs of mice caused a rapid induction of epidermal ornithine decarboxylase (ODC). A maximum induction of over 60-fold was seen at 6 hr after ap plication of 50 µl of PBCO. Concurrently, epidermal putrescine levels were elevated 4.7-fold over controls. Intraperitoneal administration of PBCO led to a 15-20-fold increase in hepatic ODC activity but to a 45% decrease in the renal enzyme activity. Maximum induction of ODC was seen at 12 hr following the administration of 4 ml/kg body wt of PBCO. Hepatic putrescine levels were elevated 34-fold over controls. Pretreatment of mice with the protein synthesis inhibitor cycloheximide abolished both epidermal and hepatic ODC induction.


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