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© 1987 Oxford University Press

research-article

Developmental Toxicity Evaluation of Inhaled Nitrobenzene in CD Rats1,2

R. W. TYL*, K. A. FRANCE*, L. C. FISHER*, D. E. DODD*, I. M. PRITTS*, J. P. LYON{dagger}, F. O. O'NEAL{ddagger} and G. KIMMERLE§

*Bushy Run Research Center Export, Pennsylvania 15632 {dagger}ICI Americas Wilmington, Delaware 19897 {ddagger}E. 1. duPont de Nemours and Company Newark, Delaware 19714 §Bayer AG Wuppertal, West Germany

Developmental Toxicity Evaluation of Inhaled Nitrobenzene in CD Rats. TYL, R. W., FRANCE, K. A., FISHER, L. C., DODD, D. E., PRITTS, I. M, LYON, J. P., O'NEAL, F. O., and KIMMERLE, G. (1987). Fundam. Appl. Toxicol. 8, 482–492. Pregnant CD (Sprague–Dawley) rats were exposed to nitrobenzene vapor (CAS Registry No. 98-95-3) at 0, 1, 10, and 40 ppm (mean analytical values of 0.0, 1.06, 9.8, and 39.4 ppm, respectively) on gestational days (gd) 6 through 15 for 6 hr/day. At sacrifice on gd 21, fetuses were evaluated for external, visceral, and skeletal malformations and variations. Maternal toxicity was observed: weight gain was reduced during exposure (gd 6–9 and 6–15) to 40 ppm, with full recovery by gd 21, and absolute and relative spleen weights were increased at 10 and 40 ppm. There was no effect of treatment on maternal liver, kidney, or gravid uterine weights, on pre- or postimplantation loss including resorptions or dead fetuses, on sex ratio of live fetuses, or on fetal body weights (male, female, or total) per litter. There were also no treatment-related effects on the incidence of fetal malformations or variations. In summary, during organogenesis in CD rats, there was no developmental toxicity (including teratogenicity) associated with exposure to nitrobenzene concentrations that produced some maternal toxicity (10 and 40 ppm) or that produced no observable maternal toxicity (1 ppm).


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