Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by DODD, D. E.
Right arrow Articles by KIMMERLE, G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by DODD, D. E.
Right arrow Articles by KIMMERLE, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1987 Oxford University Press

research-article

Reproduction and Fertility Evaluations in CD Rats following Nitrobenzene Inhalation1,2

D. E. DODD*, E. H. FOWLER*, W. M. SNELLINGS*, I. M. PRITTS*, R. W. TYL*, J. P. LYON{dagger}, F. O. O'NEAL{ddagger} and G. KIMMERLE§

*BushyRun Research Center Export, Pennsylvania 15632 {dagger}ICI Americas Wilmington, Delaware 19897 {ddagger}E. I. duPont de Nemours and Company Newark, Delaware 19714 §Bayer AG Wuppertal, West Germany

Reproduction and Fertility Evaluations in CD Rats following Nitrobenzene Inhalation. DODD, D. E., FOWLER, E. H., SNELLINGS, W. M., PRITTS, I. M., TYL, R. W., LYON, J. P., O'NEAL, F. O., and KIMMERLE, G. (1987). Fundam. Appl. Toxicol. 8, 493–505. A two-generation reproduction study was performed by exposure of Sprague–Dawley CD rats to concentrations of 40, 10, 1, or 0 (control) ppm of nitrobenzene (NB) vapor. No NB-related effects on reproduction were observed at 10 or 1 ppm. At 40 ppm, a decrease in the fertility index of the F0 and F1 generations occurred, which was associated with alterations in the male reproductive organs. Specifically, weights of testes and epididymides were reduced and seminiferous tubule atrophy, spermatocyte degeneration, and the presence of giant syncytial spermatocytes were observed. The only significant finding in the litters derived from rats exposed to 40 ppm was an approximate 12% decrease in the mean body weight of F1 pups on Postnatal Day 21. Survival indices were unaltered. To examine the reversibility of this selective effect on male gonads, the F1 males from the 40-ppm group were allowed a 9-week nonexposure period and mated to naive females. An almost fivefold increase in the fertility index was observed, indicating at least partial functional reversibility upon removal from NB exposure. Also, the numbers of giant syncytial spermatocytes and degenerated spermatocytes were greatly reduced. The results of this study support the selection of 10 ppm of NB as the no-observable-effect level for reproduction and fertility effects in rats.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.