Skip Navigation


ToxSci Advance Access originally published online on May 12, 2004
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
80/2/218    most recent
kfh164v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Moggs, J. G.
Right arrow Articles by Orphanides, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moggs, J. G.
Right arrow Articles by Orphanides, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Toxicological Sciences 80, 218-224 (2004)
Toxicological Sciences vol. 80 no. 2 © Society of Toxicology 2004; all rights reserved.

REVIEW

The Role of Chromatin in Molecular Mechanisms of Toxicity

Jonathan G. Moggs1 and George Orphanides

Syngenta CTL, Cheshire SK10 4TJ, United Kingdom

Received March 17, 2004; accepted April 29, 2004

Eukaryotic cells store their genetic information in the form of a highly organized nucleoprotein complex termed chromatin. The high degree of compaction of DNA within chromatin places severe constraints on proteins that require access to the DNA template to facilitate gene transcription, DNA replication, and DNA repair. As a consequence, eukaryotic cells have developed sophisticated mechanisms to allow chromatin to be rapidly decompacted locally for access by DNA-binding proteins. Once thought to play only a structural role, it now appears that chromatin plays a key regulatory role by marshalling access to the DNA template. We have reviewed the role played by chromatin in the cellular response to physiological and toxicological stimuli and described how changes in chromatin structure may in the future be used as markers of toxicity. We also review the evidence that chromatin itself is the direct target of certain toxicants and that toxicant-induced perturbations in chromatin structure may precipitate adverse effects.

Key Words: chromatin; histone; toxicology; genome; epigenetic.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CarcinogenesisHome page
D. M. van Leeuwen, M. Pedersen, P. J.M. Hendriksen, A. Boorsma, M. H.M. van Herwijnen, R. W.H. Gottschalk, M. Kirsch-Volders, L. E. Knudsen, R. J. Sram, E. Bajak, et al.
Genomic analysis suggests higher susceptibility of children to air pollution
Carcinogenesis, May 1, 2008; 29(5): 977 - 983.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
D. Desaulniers, G.-H. Xiao, K. Leingartner, I. Chu, B. Musicki, and B. K. Tsang
Comparisons of Brain, Uterus, and Liver mRNA Expression for Cytochrome P450s, DNA Methyltransferase-1, and Catechol-O-Methyltransferase in Prepubertal Female Sprague-Dawley Rats Exposed to a Mixture of Aryl Hydrocarbon Receptor Agonists
Toxicol. Sci., July 1, 2005; 86(1): 175 - 184.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.