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ToxSci Advance Access originally published online on September 29, 2004
Toxicological Sciences 2004 82(2):363-366; doi:10.1093/toxsci/kfh293
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Toxicological Sciences vol. 82 no. 2 © Society of Toxicology 2004; all rights reserved.

FORUM

Human Carcinogenic Risk Evaluation, Part V: The National Toxicology Program Vision for Assessing the Human Carcinogenic Hazard of Chemicals

John R. Bucher1 and Christopher Portier

National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709

Received September 7, 2004; accepted September 22, 2004

The National Toxicology Program (NTP) has over 25 years of experience in the design, performance, and interpretation of assays for identifying carcinogenic hazards to humans. Through the years we have examined alternative assays and adjunct assays to the standard rodent cancer bioassay including batteries of genetic toxicity tests and genetically modified mouse models. As our collective understanding of carcinogenesis advances, toxicologists and regulatory scientists will at some point begin to rely on mechanism-based biological observations rather than the two-year rodent bioassay to predict human cancer hazards. The goal of the NTP Vision for the 21st Century is to develop the science base that will advance the use of mechanism-based biological observations, eventually providing a replacement for disease-specific toxicology models in the protection of public health.

Key Words: carcinogen identification; approach; mechanism-based biological observations.


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