Skip Navigation


ToxSci Advance Access originally published online on October 6, 2004
Toxicological Sciences 2004 82(2):656-660; doi:10.1093/toxsci/kfi002
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
82/2/656    most recent
kfi002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Perrien, D. S.
Right arrow Articles by Lumpkin, C. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perrien, D. S.
Right arrow Articles by Lumpkin, C. K., Jr.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Toxicological Sciences vol. 82 no. 2 © Society of Toxicology 2004; all rights reserved.

IL-1 and TNF Antagonists Prevent Inhibition of Fracture Healing by Ethanol in Rats

Daniel S. Perrien*,{dagger},{ddagger}, Elizabeth C. Wahl*, William R. Hogue{ddagger},||, Ulrich Feige§, James Aronson*,¶,||, Martin J. J. Ronis|||,||||, Thomas M. Badger|||| and Charles K. Lumpkin, Jr.*,¶,1

* Laboratory for Limb Regeneration Research, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas 722021; {dagger} Department of Physiology and Biophysics, {ddagger} The Center for Orthopaedic Research, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; § Department of Inflammation Research, Amgen, Inc., Thousand Oaks, California 91320; Department of Pediatrics, || Department of Orthopaedic Surgery, ||| Department of Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; and |||| Arkansas Children's Nutrition Center, Little Rock, Arkansas 72202

Received June 1, 2004; accepted September 22, 2004

We tested the hypothesis that combined administration of IL-1 and TNF antagonists would protect fracture healing from inhibition by chronic ethanol exposure. Adult male rats were fed a liquid diet ± ethanol (CON and ETOH) by intragastric infusion for three weeks prior to and three weeks after creation of an externally fixated tibial fracture. Beginning the day of fracture, one-half of each dietary group received 2.0 mg/kg/day IL-1ra and 2.0 mg/kg/2-days sTNFR1 (CON + ANTAG and ETOH + ANTAG), while all other animals received vehicle alone (CON + VEH and ETOH + VEH). Scoring of ex vivo radiographs and analysis by pQCT revealed a significantly lower incidence of bridging and reduced total mineral content in the ETOH + VEH group compared to all other groups. These results support, for the first time, the hypothesis that IL-1 and TNF antagonists are capable of protecting fracture healing from the inhibition associated with chronic ethanol consumption.

Key Words: alcohol; tumor necrosis factor; interleukin-1; interleukin-1 recombinant antagonist; repair; total enteral nutrition.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Bone Joint Surg BrHome page
M. S. Gaston and A. H. R. W. Simpson
Inhibition of fracture healing
J Bone Joint Surg Br, December 1, 2007; 89-B(12): 1553 - 1560.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.