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ToxSci Advance Access originally published online on January 5, 2005
Toxicological Sciences 2005 84(2):243-248; doi:10.1093/toxsci/kfi079
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Toxicological Sciences vol. 84 no. 2 © The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Induction of Colon Tumors in C57BL/6J Mice Fed MeIQx, IQ, or PhIP Followed by Dextran Sulfate Sodium Treatment

Akiyoshi Nishikawa1, Takayoshi Imazawa, Yuichi Kuroiwa, Yasuki Kitamura, Keita Kanki, Yuji Ishii, Takashi Umemura and Masao Hirose

Division of Pathology, National Institute of Health Sciences, 1–18–1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan

Received November 19, 2004; accepted January 2, 2005

Heterocyclic amines (HCAs) have been shown to induce tumors in several organs of rodents, but except for MeIQ and PhIP, other HCAs such as MeIQx and IQ consistently failed to induce colon tumors in mice, whereas MeIQ, IQ, and PhIP exerted colon tumorigenicity in rats. Recently, we found that dietary MeIQx induces genotoxicity in the colon as well as the liver of two different types of reporter gene transgenic mice at subcarcinogenic doses such as 300 ppm. However, in the present study, dietary MeIQx did not significantly induce any tumors in C57BL/6J mice or gpt delta mice even when fed at 300 ppm for 78 weeks, suggesting that the treatment of MeIQx alone was not sufficient to promote colon tumors. In order to clarify a possibility whether such HCAs can induce colon tumors, C57BL/6J mice were fed MeIQx, IQ, or PhIP at a dose of 300 ppm for 12 weeks and, thereafter, twice received 1-week treatment with dextran sulfate sodium (DSS), 2 weeks apart. After 20 weeks, colon tumors including adenocarcinomas were found at incidences of 22%, 24%, and 45% in the groups receiving MeIQx, IQ, and PhIP, respectively, which were significantly (p < 0.05 or 0.01) different from the DSS alone value (0%). Thus our results clearly indicate that, in addition to PhIP, MeIQx and IQ can induce colon tumors in mice under an experimental condition promoting colon tumors.

Key Words: MeIQx; heterocyclic amime; colon tumor; dextran sulfate sodium; mouse.


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