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ToxSci Advance Access originally published online on March 2, 2005
Toxicological Sciences 2005 85(2):898-905; doi:10.1093/toxsci/kfi137
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Toxicological Sciences vol. 85 no. 2 © The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Acute Cardiopulmonary Alterations Induced by Fine Particulate Matter of São Paulo, Brazil

Dolores Helena Rodriguez Ferreira Rivero*,1, Sandra Regina Castro Soares*, Geraldo Lorenzi-Filho{dagger}, Mitiko Saiki{ddagger}, John J. Godleski§, Leila Antonangelo*, Marisa Dolhnikoff* and Paulo Hilário Nascimento Saldiva*

* Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil; {dagger} Pulmonary Division, School of Medicine, University of São Paulo, Experimental Air Pollution Laboratory, São Paulo, Brazil; {ddagger} Institute of Research in Nuclear Energy of the State of São Paulo, São Paulo, Brazil; § Department of Environmental Health, Physiology Program, Harvard School of Public Health, Boston, Massachusetts

Received October 14, 2004; accepted February 13, 2005

The mechanisms involved in the association between air pollution and increased cardiovascular morbidity are not fully understood. The objective of this study was to test the hypothesis that fine particulate matter (PM2.5) induces systemic inflammation and vasoconstriction of small arteries in the lung and heart of rats. Thirty-eight healthy Wistar rats were anesthetized, intubated, and submitted to the instillation of 1 ml of distilled water diluted in the following solution: blank filter, 100 µg and 500 µg of PM2.5. PM2.5 was collected in glass fiber filters with a high-volume sampler. The animals were sacrificed 24 h after instillation when blood, heart, and lung samples were collected for morphological and wet-to-dry weight ratio analysis. PM2.5 consisted of the following elements: sulphur, arsenic, bromine, chlorine, cobalt, iron, lanthanum, manganese, antimony, scandium, and thorium. Total reticulocytes significantly increased at both PM2.5 doses (p < 0.05) while hematocrit levels increased in the 500 µg group (p < 0.05). Quantification of segmented neutrophils and fibrinogen levels showed a significant decrease, while lymphocytes counting increased with 100 µg of PM2.5 (p < 0.05). A significant dose-dependent decrease of intra-acinar pulmonary arteriole lumen/wall ratio (L/W) was observed in PM groups (p < 0.001). Peribronchiolar arterioles L/W showed a significant decrease in the 500 µg group (p < 0.001). A significant increase in heart wet-to-dry weight ratio was observed in the 500 µg group (p < 0.001). In conclusion, fine environment particles in the city of São Paulo promote pulmonary and cardiac histological alterations. Pulmonary vasculature was markedly affected by particle instillation, resulting in significant vasoconstriction in healthy rats.

Key Words: particulate matter; blood; vasoconstriction; lung; heart.


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