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ToxSci Advance Access originally published online on April 20, 2005
Toxicological Sciences 2005 86(1):125-131; doi:10.1093/toxsci/kfi174
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Coplanar PCB Congeners Increase Uterine Weight and Frontal Cortical Dopamine in the Developing Rat: Implications for Developmental Neurotoxicity

Richard F. Seegal*,{dagger},1, Karl O. Brosch* and Richard J. Okoniewski*

* New York State Department of Health, Wadsworth Center, Albany, New York; {dagger} University at Albany, School of Public Health, Albany, New York 12201–0509

Received February 17, 2005; accepted April 13, 2005

We show that developmental exposure of the laboratory rat to the coplanar polychlorinated biphenyl (PCB) congener 3,4,3',4'-tetrachlorobiphenyl (TCB) and the structurally similar congener 3,4,5,3',4'-pentachlorobiphenyl (PtCB) elevates dopamine (DA) concentrations in the prefrontal cortex (PFC). To determine whether these coplanar congeners are estrogenic, and may thus contribute to the elevations in PFC DA, we measured uterine wet weight (UWW) in prepubertal rats exposed to TCB or PtCB. For comparison, additional animals were exposed to either the ortho-substituted congener 2,4,2',4'-tetrachlorobiphenyl (o-TCB) or 3,4,5,3',4',5'-hexachlorobiphenyl (HCB), a coplanar congener highly resistant to metabolism. Both TCB and PtCB increased UWW, but this effect was blocked after exposure to the anti-estrogen ICI 182,780. Neither o-TCB nor HCB altered UWW. These results demonstrate that certain coplanar PCB congeners and/or their metabolites, are estrogenic, and suggest that exposure during critical periods of neuronal development may increase central DA concentrations, and by inference, alter behavior.

Key Words: polychlorinated biphenyls; coplanar; uterotropic; brain; dopamine; developmental neurotoxicity.


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