ToxSci Advance Access originally published online on August 24, 2005
Toxicological Sciences 2005 88(1):12-17; doi:10.1093/toxsci/kfi293
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Research Strategies for Safety Evaluation of Nanomaterials, Part II: Toxicological and Safety Evaluation of Nanomaterials, Current Challenges and Data Needs
* ILSI Health and Environmental Sciences Institute, One Thomas Circle, NW, 9th Floor, Washington, District of Columbia 20005; Office of Research and Development, US Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, District of Columbia 20460; Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Building 1803, Midland, Michigan 48674; Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606; ¶ Central Product Safety, Procter & Gamble Co., Miami Valley Labs, PO Box 538707, Cincinnati, Ohio 45253; || National Institute of Environmental Health Sciences, 11 Alexander Drive, Research Triangle Park, North Carolina 27709; and ||| ILSI Health and Environmental Sciences Institute, One Thomas Circle, NW, 9th Floor, Washington, District of Columbia 20005
Received March 2, 2005; accepted August 18, 2005
This article summarizes a roundtable discussion held at the 2005 Society of Toxicology Annual Meeting in New Orleans, LA. The purpose of the roundtable was to review the current challenges and data needs for conducting toxicological and safety evaluations for nanomaterials, with the goals of presenting the current state-of-the science on the safety of nanomaterials and bringing together scientists representing government, academia, and industry to identify priorities for developing data to facilitate risk assessments for these materials. In this summary, the unique physicochemical properties associated with nanomaterials are reviewed in the context of the difficulties associated with measuring and characterizing them. In addition, the development of appropriate hazard data, the collection of accurate human and environmental exposure information, and the development of a better fundamental understanding of the modes of action for nanomaterials are discussed as factors that will impact the development of comprehensive toxicological and safety evaluations.
Key Words: nanomaterials; nanoscale materials; nanotechnology; risk assessment; toxicology.
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