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ToxSci Advance Access originally published online on August 17, 2005
Toxicological Sciences 2005 88(2):307-310; doi:10.1093/toxsci/kfi277
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

FORUM

In Silico Methods for Evaluating Human Allergenicity to Novel Proteins: International Bioinformatics Workshop Meeting Report, 23–24 February 2005

Karluss Thomas*,1, Gary Bannon{dagger}, Susan Hefle{ddagger}, Corinne Herouet§, Michael Holsapple*, Gregory Ladics, Sue MacIntosh|| and Laura Privalle|||

* International Life Sciences Institute Health and Environmental Sciences Institute, One Thomas Circle NW, Ninth Floor, Washington, District of Columbia 20005; {dagger} Monsanto Co., 800 North Lindbergh Boulevard, St. Louis, Missouri 63167; {ddagger} Food Allergy Research and Resource Program, University of Nebraska, 255 Food Industry Building, Lincoln, Nebraska 68583; § Bayer CropScience, Regulatory Toxicology, 355 rue Doistoïevski, Sophia Antipolis, France; E.I. Dupont De Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, P.O. Box 50 1090 Elkton Road, Newark, Delaware 19714; || Bayer CropScience, P.O. Box 12014, 2 T.W. Alexander Drive, Research Triangle Park, North Carolina 27709; and ||| BASF Plant Science, 26 Davis Drive, Research Triangle Park, North Carolina 27709

Received June 14, 2005; accepted August 1, 2005

The ILSI Health and Environmental Sciences Institute (HESI) hosted an expert workshop 22–24 February 2005 in Mallorca, Spain, to review the state-of-the-science for conducting a sequence homology/bioinformatics evaluation in the context of a comprehensive allergenicity assessment for novel proteins, to obtain consensus on the value and role of bioinformatics in evaluating novel proteins, and to discuss the utility and methods of allergen-specific IgE testing in the diagnosis of food allergy. The workshop participants included over forty international experts from academia, industry, and government. The workshop was hosted by the HESI Protein Allergenicity Technical committee, which has established a long-term program whose mission is to advance the scientific understanding of the relevant parameters for characterizing the allergenic potential of novel proteins.

Key Words: allergy; antibody; antigen; IgE; food allergy; immunoglobulin.


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