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Toxicological Sciences 2006 89(1):1-3; doi:10.1093/toxsci/kfj034
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

TOXICOLOGICAL HIGHLIGHT

The TRPV1 Receptor: Target of Toxicants and Therapeutics

Bellina Veronesi*,1 and Marga Oortgiesen{dagger}

* National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Neurotoxicology Division–Cellular and Molecular Branch, Mail Drop B105–06, Research Triangle Park, North Carolina 27711, and {dagger} Cato Research Ltd., Integrated Drug Development, Durham, North Carolina 27713

Received October 27, 2005; accepted October 28, 2005

ABSTRACT

Understanding the structural and functional complexities of the transient receptor potential vanilloid receptor (TRPV1) is essential to the therapeutic modulation of inflammation and pain. Because of its central role in initiating inflammatory processes and integrating painful stimuli, there is an understandable interest in its pharmacological manipulation (sensitization/desensitization). The present Highlight entitled "TRPV1 antagonists elevate cell surface populations of receptor protein and exacerbate TRPV1 mediated toxicities in human lung epithelial cells" describes how exposure to various antagonists produces TRPV1 sensitization and proposes a possible mechanistic explanation to that sensitization.

Key Words: TRPV1; capsaicin receptor; neurogenic inflammation; respiratory inflammation; BEAS-2B; particulate matter.


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