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ToxSci Advance Access originally published online on October 19, 2005
Toxicological Sciences 2006 89(1):338-347; doi:10.1093/toxsci/kfj027
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Toxicity and Tissue Distribution of Magnetic Nanoparticles in Mice

Jun Sung Kim*,1, Tae-Jong Yoon{dagger},1, Kyeong Nam Yu*, Byung Gul Kim{dagger}, Sung Jin Park*, Hyun Woo Kim*, Kee Ho Lee{ddagger}, Seung Bum Park§, Jin-Kyu Lee{dagger} and Myung Haing Cho*,2

* Laboratory of Toxicology, College of Veterinary Medicine and School of Agricultural Biotechnology, {dagger} Materials Chemistry Laboratory, § Chemical Biology Laboratory, School of Chemistry (NS60), Seoul National University, Seoul 151–742, and {ddagger} Laboratory of Molecular Oncology, Korea Institute of Radiological & Medical Sciences, Seoul 139–240, Korea

Received July 2, 2005; accepted October 7, 2005

The development of technology enables the reduction of material size in science. The use of particle reduction in size from micro to nanoscale not only provides benefits to diverse scientific fields but also poses potential risks to humans and the environment. For the successful application of nanomaterials in bioscience, it is essential to understand the biological fate and potential toxicity of nanoparticles. The aim of this study was to evaluate the biological distribution as well as the potential toxicity of magnetic nanoparticles to enable their diverse applications in life science, such as drug development, protein detection, and gene delivery. We recently synthesized biocompatible silica-overcoated magnetic nanoparticles containing rhodamine B isothiocyanate (RITC) within a silica shell of controllable thickness [MNPs@SiO2(RITC)]. In this study, the MNPs@SiO2(RITC) with 50-nm thickness were used as a model nanomaterial. After intraperitoneal administration of MNPs@SiO2(RITC) for 4 weeks into mice, the nanoparticles were detected in the brain, indicating that such nanosized materials can penetrate blood–brain barrier (BBB) without disturbing its function or producing apparent toxicity. After a 4-week observation, MNPs@SiO2(RITC) was still present in various organs without causing apparent toxicity. Taken together, our results demonstrated that magnetic nanoparticles of 50-nm size did not cause apparent toxicity under the experimental conditions of this study.

Key Words: magnetic nanoparticles; blood-brain barrier.


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