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© 1987 Oxford University Press

research-article

Subchronic Inhalation Toxicity of Hexamethylenediamine in Rats

F. R. JOHNNSEN*, G. J. LEVINSKAS*, R. BEN-DYKE{dagger},1 and G. K. HOGAN{dagger}

*Monsanto Company 800 N. Lindbergh Boulevard St. Louis, Missouri 63167 {dagger}Bio/dynamics, Inc. Mettlers Road, East Millstone, New Jersey 08873

Four groups of 15 male and 15 female Sprague-Dawley-derived (CD) rats each were exposed to aqueous hexamethylenediamine (HMD) aerosols for 6 hr/thy, 5 days/week for 13 weeks at mean analytical concentrations of 0, 12.8, or 51 mg/m3 Because of exposure-related deaths in a group of male and female rats similarly exposed to 215 mg/m3 HMD, this group was terminated during the seventh week of the study. Signs of respiratory and conjunctival irritation were observed in rats at both the 51 and 215 mg/m3 HMD test levels. Body weight gain was significantly reduced in both sexes exposed to 215 mg/m3 HMD. At the 5-week study interval, slight hemopoietic stimulation of peripheral blood parameters was observed in rats of both sexes exposed to 215 mg/m3 HMD. Treatment-related microscopic lesions were seen only in rats exposed to 215 mg/m3 MD and were confined to the trachea, nasal passages, and lungs. The noeffect level in this study is considered to be 12.8 mg/m3 HMD.


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